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Related Concept Videos

Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Jul 18, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Prenatal diagnosis of chromosomal abnormalities using array-based comparative genomic hybridization.

Trilochan Sahoo1, Sau Wai Cheung, Patricia Ward

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

Genetics in Medicine : Official Journal of the American College of Medical Genetics
|November 17, 2006
PubMed
Summary

This study shows that targeted array comparative genomic hybridization (array-CGH) is a feasible method for prenatal diagnosis of genomic imbalances. It offers enhanced screening for chromosomal abnormalities in high-risk pregnancies.

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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

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Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

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FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Area of Science:

  • Genetics
  • Prenatal Diagnostics
  • Genomic Medicine

Background:

  • Prenatal diagnosis traditionally relies on karyotyping.
  • Genomic imbalances can cause significant developmental issues.
  • Advanced techniques are needed to improve detection rates.

Purpose of the Study:

  • To evaluate the feasibility of targeted array-CGH for prenatal diagnosis.
  • To assess array-CGH as a clinical tool for detecting genomic imbalances.
  • To compare array-CGH with routine chromosome analysis.

Main Methods:

  • Array-CGH (BCM V4.0) was offered alongside routine chromosome analysis.
  • DNA was analyzed from amniotic fluid, chorionic villus samples, and cultured cells.
  • Whole genome amplification was used for direct sample analysis.

Main Results:

  • Ninety-eight pregnancies were analyzed with complete concordance between array-CGH and karyotype.
  • Five cases with chromosomal abnormalities were detected.
  • Array-CGH detected copy number variations requiring parental testing in 12 cases.
  • Results were available in an average of 6 days for direct analysis.

Conclusions:

  • Array-CGH is feasible for prenatal diagnosis, including direct analysis without cell culturing.
  • This method enhances the detection of chromosomal abnormalities.
  • Array-CGH is a valuable option for enhanced screening in high-risk pregnancies.