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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Adhesion molecules in chronic ulcerative colitis.
Maya V Gulubova1, Irena M Manolova, Tatyana I Vlaykova
1Department of General and Clinical Pathology, Medical Faculty, Trakia University, Armeiska Street 11, Stara Zagora, 6000, Bulgaria. mgulubova@hotmail.com
International Journal of Colorectal Disease
|November 17, 2006
Summary
Adhesion molecules like ICAM-1 and VCAM-1 are crucial in active ulcerative colitis (UC). Their expression decreases in UC remission, indicating a role in maintaining chronic inflammation.
Area of Science:
- Gastroenterology
- Immunology
- Cell Biology
Background:
- Adhesion molecule expression in colonic mucosa is key for ulcerative colitis (UC) activity.
- Understanding these molecules helps differentiate active UC from remission.
Purpose of the Study:
- To profile adhesion molecules in colonic mucosa during active UC and remission.
- To investigate the role of specific adhesion molecules in UC pathogenesis.
Main Methods:
- Immunohistochemistry on colonic biopsy specimens from 14 UC patients (active and remission) and 7 controls.
- Antibodies used: ICAM-1, VCAM-1, E-selectin, LFA-1, Mac-1, and VLA-4.
Main Results:
- UC patients showed increased ICAM-1, VCAM-1, and E-selectin on endothelial cells.
- Active UC featured numerous inflammatory cells positive for ICAM-1, LFA-1, VCAM-1, Mac-1, and VLA-4.
- UC in remission had significantly fewer inflammatory cells expressing these adhesion molecules.
Conclusions:
- ICAM-1, VCAM-1, LFA-1, and VLA-4 play a significant role in lymphocyte and macrophage adherence, sustaining chronic inflammation in UC.
- E-selectin presence on venule endothelium may signal potential relapse in UC patients.
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