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Updated: Jul 18, 2026
06:39
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
Pattern of double glomerulopathy in children.
Hae Il Cheong1, Hee Yeon Cho, Kyung Chul Moon
1Department of Pediatrics, Seoul National University Children's Hospital, 28 Yongon-Dong, Chongro-Gu, Seoul 110-744, South Korea. cheonghi@snu.ac.kr
Pediatric Nephrology (Berlin, Germany)
|November 17, 2006
Summary
Double glomerulopathy in children, the coexistence or superimposition of two distinct kidney diseases, occurs in 3.1% of cases. These conditions often arise coincidentally, with superimposed acute symptoms frequently resolving.
Area of Science:
- Pediatric Nephrology
- Renal Pathology
Background:
- Double glomerulopathy, defined as coexisting or superimposed renal diseases, has been reported sporadically in pediatric cases.
- Understanding the incidence and characteristics of double glomerulopathy in children is crucial for accurate diagnosis and management.
Observation:
- A retrospective review of 294 pediatric renal biopsies identified 9 cases (3.1%) of double glomerulopathy.
- Seven cases presented with coexisting glomerulopathies, while two involved superimposed glomerulopathy diagnosed via repeat biopsy.
Findings:
- Primary glomerulopathies included chronic conditions like Alport syndrome and IgA nephropathy.
- Superimposed glomerulopathies were common pediatric types such as postinfectious glomerulonephritis and Henoch-Schönlein nephritis.
- The study suggests double glomerulopathy often results from the coincidental occurrence of two independent conditions.
Implications:
- Double glomerulopathy is not rare in children and frequently occurs by chance.
- Atypical changes in a child's glomerulopathy course may indicate superimposed disease.
- The long-term impact of superimposed glomerulopathy on renal function requires further investigation.
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