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Cancer gene therapy targeting angiogenesis: an updated review

Ching-Chiu Liu1, Zan Shen, Hsiang-Fu Kung

  • 1Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong, China.

World Journal of Gastroenterology
|November 17, 2006
PubMed

Insights

Targeting tumor growth via anti-angiogenesis gene therapy is a promising cancer treatment. This review covers strategies and vectors for delivering anti-angiogenesis genes, offering localized and sustained therapeutic effects.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • The link between angiogenesis and tumor growth has been recognized since 1971.
  • Anti-angiogenesis therapy aims to inhibit tumor vascularization.
  • Current approaches include inhibiting growth factors and using angiogenesis inhibitors.

Purpose of the Study:

  • To review current strategies in anti-angiogenesis cancer gene therapy.
  • To discuss various vectors used for gene transfer in this context.
  • To highlight advancements in localized and sustained gene expression within tumors.

Main Methods:

  • Review of scientific literature on anti-angiogenesis gene therapy.
  • Analysis of different recombinant vector systems for gene delivery.
  • Evaluation of studies focusing on therapeutic gene product expression in tumors.

Main Results:

  • Gene transfer offers a promising approach for anti-angiogenesis therapy.
  • Advancements in recombinant vectors facilitate localized and sustained gene expression.
  • Various strategies and vectors are being explored for cancer treatment.

Conclusions:

  • Anti-angiogenesis gene therapy presents a viable strategy for cancer treatment.
  • Recombinant vectors are crucial for effective localized and sustained therapeutic gene delivery.
  • Continued research into strategies and vectors will advance this field.

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