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Published on: October 6, 2015
Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis
Annemarie E Brouwer1, Asna A Siddiqui, Maartje I Kester
1Centre for Infection, St. George's University of London, Cranmer Terrace, London SW17 ORE, UK.
Abstract:
The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-gamma, TNF-alpha, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.
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