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Updated: Jul 18, 2026

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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Clinically occult cutaneous metastases.
Kenneth S Resnik1, Mario DiLeonardo, George Gibbons
1Institute for Dermatopathology, Conshohocken, Pennsylvania 19428, USA. kresnik@ameripath.com
Journal of the American Academy of Dermatology
|November 18, 2006
Summary
Clinically unrecognized cutaneous metastases, often presenting as papules, nodules, or tumors, can be detected incidentally during histopathological examination. This study highlights a unique presentation of these skin metastases.
Area of Science:
- Oncology
- Dermatopathology
- Cancer Research
Background:
- Cutaneous metastases typically manifest with distinct clinical signs, such as indurated papules, nodules, or tumors.
- Specific clinical presentations can indicate the primary cancer type of the metastasis.
Observation:
- This case report details an unusual presentation of cutaneous metastases.
- These metastases were clinically undetectable and only identified incidentally through histopathological analysis.
Findings:
- The study identified a phenomenon of 'clinically incognito' cutaneous metastases.
- These metastases were not apparent on physical examination but were confirmed microscopically.
Implications:
- This finding expands the spectrum of how cutaneous metastases can present.
- Awareness of this presentation is crucial for accurate diagnosis and patient management.
- Histopathological examination plays a vital role in detecting subtle or unexpected metastatic disease.
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