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Possible pathogenic nature of the recently discovered TT virus: does it play a role in autoimmune rheumatic diseases?
Peter Gergely1, Andras Perl, Gyula Poór
1National Institute of Rheumatology and Physiotherapy, Frankel Leó u 38-40, H-1023 Budapest, Hungary.
Abstract:
Pathogenesis of viral origin has long been suggested in autoimmune rheumatic diseases. Beside the well-defined virus induced transient or chronic rheumatic diseases often resembling systemic autoimmune disorders such as rheumatoid arthritis, viruses can contribute to disease pathogenesis by several different pathomechanisms. TT virus is a recently discovered virus of extremely high genetic diversity which commonly infects humans. Despite accumulated evidence on the biological characteristics of TTV, its pathogenicity is still in question; many consider TTV as a harmless endosymbiont. The recent paper overviews the biology of TT virus and investigates the hypothesis that TTV might have a causative role in human diseases with special attention to the possibility that TTV might trigger autoimmunity in rheumatic disorders.
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