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Updated: Jul 18, 2026
06:03
Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis
Published on: July 12, 2011
Serum amyloid A in autoimmune thrombosis
S Sodin-Semrl1, P Zigon, S Cucnik
1University Medical Centre, Division of Internal Medicine, Department of Rheumatology, Vodnikova 62, SI-1000 Ljubljana, Slovenia.
Autoimmunity Reviews
|November 18, 2006
Summary
Serum amyloid A (SAA), C-reactive protein (CRP), and interleukin-6 (IL-6) show correlations with autoimmune diseases. SAA may predict progression from non-inflammatory to inflammatory thrombotic conditions.
Area of Science:
- Immunology
- Rheumatology
- Clinical Chemistry
Background:
- Autoimmune diseases like systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are associated with inflammation and thrombosis.
- Biomarkers such as serum amyloid A (SAA), high-sensitivity C-reactive protein (CRP), and interleukin-6 (IL-6) are implicated in inflammatory processes.
Purpose of the Study:
- To investigate the correlation between SAA, CRP, and IL-6 levels and autoimmune diseases, with or without thrombosis.
- To identify parameters influencing SAA levels in patients with autoimmune conditions.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify SAA, CRP, and IL-6 concentrations.
- Patient groups included secondary antiphospholipid syndrome (SAPS), primary antiphospholipid syndrome (PAPS), SLE with antiphospholipid antibodies (SLE+aPL), SLE, venous thrombosis (VT), and arterial thrombosis (AT).
- These patient groups (n=84) were compared to healthy donors (n=60).
Main Results:
- Elevated levels of SAA, CRP, and IL-6 were observed in SAPS, SLE, and SLE+aPL patient groups compared to healthy donors.
- Significant differences in all three markers were found between healthy individuals and inflammatory patient groups (SAPS and SLE+aPL).
- SAA and CRP showed a stronger correlation in SAPS patients than in SLE+aPL patients.
Conclusions:
- SAA is not a reliable marker for venous thrombosis, arterial thrombosis, or PAPS.
- SAA may serve as a predictive marker for the transition of non-inflammatory thrombotic conditions to inflammatory states.
- Further research is needed due to the limitations of this small, retrospective study.
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