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Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching

Andrey Revyakin1, Chenyu Liu, Richard H Ebright

  • 1Howard Hughes Medical Institute, Waksman Institute, and Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA.

Science (New York, N.Y.)
|November 18, 2006
PubMed
Summary

Abortive initiation and promoter escape involve DNA scrunching, where RNA polymerase pulls DNA into itself. This process requires RNA synthesis and generates a stressed intermediate, driving the release of interactions.

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