Related Experiment Video
Updated: Jul 18, 2026

Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
New strategies for the elimination of polio from India
Nicholas C Grassly1, Christophe Fraser, Jay Wenger
1Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, UK. n.grassly@imperial.ac.uk
Abstract:
The feasibility of global polio eradication is being questioned as a result of continued transmission in a few localities that act as sources for outbreaks elsewhere. Perhaps the greatest challenge is in India, where transmission has persisted in Uttar Pradesh and Bihar despite high coverage with multiple doses of vaccine. We estimate key parameters governing the seasonal epidemics in these areas and show that high population density and poor sanitation cause persistence by not only facilitating transmission of poliovirus but also severely compromising the efficacy of the trivalent vaccine. We analyze strategies to counteract this and show that switching to monovalent vaccine may finally interrupt virus transmission.
Related Concept Videos
Poliomyelitis
Smallpox
Respiratory Syncytial Virus Disease
Vaccinations
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Pharmaceutical Poisoning: Treatment Strategies

