Related Experiment Video
Updated: Jul 18, 2026
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Pregnancy and chronic progressive pulmonary disease
Isaiah D Wexler1, Marie Johannesson, Frank P Edenborough
1Department of Pediatrics and CF Center, Hadassah University Hospital-Mount Scopus Campus, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
American Journal of Respiratory and Critical Care Medicine
|November 18, 2006
Summary
Pregnancy with progressive pulmonary disease, like cystic fibrosis, poses risks to mothers and fetuses. Structured physician-patient negotiations can create an ethical framework to manage conflicts and support informed decisions.
Area of Science:
- Medical Ethics
- Pulmonology
- Reproductive Health
Background:
- Progressive pulmonary diseases, including cystic fibrosis, can pose significant risks during pregnancy.
- Pregnancy in women with these conditions may lead to severe maternal and fetal complications.
- Potential conflicts arise between patient autonomy and physician's duty of care (beneficence, nonmaleficence).
Purpose of the Study:
- To propose a framework for resolving ethical conflicts between physicians and patients regarding pregnancy in women with progressive pulmonary disease.
- To outline a structured negotiation process to address moral tensions before pregnancy initiation.
- To ensure patient autonomy and professional ethical standards are upheld.
Main Methods:
- Structured negotiation process between physician and patient.
- Defining the therapeutic alliance.
- Information exchange, including discussion of pregnancy alternatives (adoption, surrogacy).
- Dialog and deliberation to reach a consensual agreement.
Main Results:
- Negotiations aim to establish an ethical framework to reduce moral tension.
- Informed discussion of risks and alternatives is crucial.
- A well-delineated consensual agreement ensures medical team support for pregnancy.
Conclusions:
- Structured negotiation is essential for resolving ethical dilemmas in pregnancy for women with progressive pulmonary disease.
- This process respects patient autonomy while adhering to medical ethics.
- Successful negotiation leads to a shared decision-making approach and supported pregnancy.
Related Concept Videos
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:23Chronic Obstructive Pulmonary Disease I: Introduction
Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
01:24Chronic Obstructive Pulmonary Disease
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD: