Related Experiment Video
Updated: Jul 18, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
Published on: January 6, 2011
Manic behaviour induced by deep-brain stimulation in Parkinson's disease: evidence of substantia nigra implication?
M Ulla1, S Thobois, J-J Lemaire
1Univ Clermont 1, UFR Médecine, Clermont-Ferrand, France. mulla@chu-clermontferrand.fr
Abstract:
We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.
Related Concept Videos
Parkinson Disease ll: Pathophysiology
Neural Regulation
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Parkinson's Disease: Overview
Alterations in Muscle Tone lll

