Related Experiment Video
Updated: Jul 18, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Relating two techniques for handling uncertainties in IMRT optimization
1Department of Medical Physics in Radiation Therapy, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. j.unkelbach@dkfz.de
Abstract:
Radiotherapy treatment planning is associated with uncertainties. Examples are uncertainties in the tumour location due to organ movement or the inter/intra observer variability in target definition. Different approaches to incorporate uncertainties into IMRT optimization have been proposed. In this note, we point out a relation between two previously published methods: the coverage probability approach and the concept of optimizing the expectation value of an objective function that depends on a set of random variables. Both concepts are generally different, but turn out to be equivalent in special cases.
More Related Videos
08:54Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
07:57Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
Related Concept Videos
Propagation of Uncertainty from Random Error
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Uncertainty: Overview
Propagation of Uncertainty from Systematic Error
Lagrange Multipliers: Two Constraints
Uncertainty: Confidence Intervals