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Towards conformal light delivery using tailored cylindrical diffusers: attainable light dose distributions.

Augusto Rendon1, Robert Weersink, Lothar Lilge

  • 1Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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Tailored fiber-optic diffusers can improve light dose confinement in therapeutic applications. This study presents a method to characterize light dose distributions from these advanced diffusers.

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Area of Science:

  • Biomedical Engineering
  • Photomedicine
  • Optical Physics

Background:

  • Interstitial light delivery is crucial for therapies, typically using fiber-optic diffusers with uniform light emission.
  • Current uniform diffusers limit precise light dose control within target tissues.
  • Emerging tailored diffusers offer potential for improved conformal light delivery.

Purpose of the Study:

  • To investigate the efficacy of tailored diffusers in enhancing light dose confinement to a target volume.
  • To develop a theoretical framework for calculating light dose from arbitrary source distributions.

Main Methods:

  • Developed a formalism for light dose calculation based on convolution with a point source function.
  • Modeled a cylindrical diffuser with a sinusoidal longitudinal emission profile.
  • Characterized attainable light dose distributions by analyzing the relationship between spatial frequency, radial distance, and isodose contour amplitude.

Main Results:

  • Demonstrated that tailored diffusers enable improved control over light dose distribution compared to uniform diffusers.
  • Established a quantitative relationship characterizing light dose confinement based on diffuser properties.
  • Showcased the potential for precise light targeting using sinusoidally emitting diffusers.

Conclusions:

  • Tailored longitudinal emission profiles significantly enhance light dose confinement for interstitial therapies.
  • The developed formalism provides a tool to predict and optimize light delivery using advanced diffusers.
  • This work paves the way for more effective and targeted photomedical treatments.