Related Experiment Video
Updated: Jul 18, 2026
07:09
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Myeloid C-type lectins in innate immunity
Matthew J Robinson1, David Sancho, Emma C Slack
1Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom.
Nature Immunology
|November 18, 2006
Summary
Myeloid C-type lectins are key in innate immunity. This study explores their signaling pathways and roles as activating or inhibitory receptors in pathogen and self recognition.
Area of Science:
- Immunology
- Molecular Biology
Background:
- C-type lectins are a protein family on myeloid cells, involved in pathogen recognition.
- Defining C-type lectin receptors requires identifying associated signaling motifs, similar to Toll-like receptors.
Purpose of the Study:
- To investigate the signaling pathways of myeloid C-type lectins.
- To explore their functions as autonomous activating or inhibitory receptors in innate immunity.
Main Methods:
- Focus on known signaling pathways.
- Analysis of receptor functions in innate responses.
Main Results:
- Detailed characterization of signaling motifs associated with myeloid C-type lectins.
- Identification of their roles in pathogen and self recognition.
Conclusions:
- Myeloid C-type lectins function as critical receptors in innate immunity.
- Understanding their signaling pathways is essential for elucidating their roles in host defense.
Related Concept Videos
01:25Selectins
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
01:31Immunoglobulin-like Cell Adhesion Molecules
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
01:40Cell-mediated Immune Responses
Overview
01:28Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
01:26Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...