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Updated: Jul 18, 2026

Synthesis of High Purity Nonsymmetric Dialkylphosphinic Acid Extractants
Published on: October 19, 2017
1-(N-chloroacetylamino)-alkylphosphonic acids - synthetic precursors of phosphonopeptides
Z H Kudzin1, R Depczyński, M H Kudzin
1Institute of Chemistry, University of Łódź, Łódź, Poland. zhk@chemul.uni.lodz.pl
Abstract:
General procedures of N-chloroacetylation of the representative 1-aminoalkylphosphonic acids (Gly(P), Ala(P), Val(P), Pgly(P) and Phe(P)) are described. These 1-(N-chloroacetylamino)-alkylphosphonic acids were converted into the corresponding glycylphosphonodipeptides (Gly-AA(P)) and/or related N-alkylglycylphosphonodipeptides (Me(n)Gly-AA(P)) in the course of ammonolysis/aminolysis. Physico-chemical properties of synthesized 1-(N-chloroacetylamino)-alkylphosphonic acids and phosphonodipeptides are characterized.
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