Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Post-traumatic alveolar changes in lung contusion].

U Obertacke1, T Joka, M Jochum

  • 1Abteilung für Unfallchirurgie, Chirurgische Klinik und Poliklinik, Universität Essen.

Der Unfallchirurg
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Infectious bacterial symphysitis (purulent infection of the pubic symphysis) in a urological setting-a descriptive study and treatment algorithm].

Urologie (Heidelberg, Germany)·2025
Same author

Restructuring the final year of the model study programme MaReCuM at the Medical Faculty Mannheim: the academic quarter in ambulatory medicine.

GMS journal for medical education·2019
Same author

> 10-year outcome of dislocated radial fractures with concomitant intracarpal lesions as proven by MRI and CT.

Archives of orthopaedic and trauma surgery·2019
Same author

[Teaching in orthopaedic and trauma surgery].

Der Orthopade·2017
Same author

Local complement activation in aqueous humor in patients with age-related macular degeneration.

Eye (London, England)·2017
Same author

Monitoring of complement activation biomarkers and eculizumab in complement-mediated renal disorders.

Clinical and experimental immunology·2016

Early lung injury after trauma involves neutrophil degranulation and protein leakage in the lungs. These reactions in patients with lung contusion resemble those seen in acute respiratory distress syndrome (ARDS).

Area of Science:

  • Pulmonary Medicine
  • Trauma Research
  • Critical Care

Background:

  • Lung contusion is a common injury following blunt chest trauma.
  • Early inflammatory responses in the lung can lead to significant morbidity and mortality.
  • Understanding these early reactions is crucial for timely intervention.

Purpose of the Study:

  • To investigate the early cellular and biochemical changes in bronchoalveolar lavage (BAL) fluid from patients with lung contusion.
  • To compare these findings with control groups and post-traumatic acute respiratory distress syndrome (ARDS).

Main Methods:

  • Bronchoalveolar lavage (BAL) was performed on nine patients with lung contusion post-trauma.
  • BAL specimens were analyzed for inflammatory markers and protein content.

Related Experiment Videos

  • Comparison with control groups and ARDS patient data.

    • Main Results:

    • Early findings include polymorphonuclear neutrophil (PMN) degranulation.
    • Increased mediator release and high protein leakage were observed in the alveolar space.
    • The extent of alveolar reactions was comparable to that seen in post-traumatic ARDS.

    Conclusions:

    • Lung contusion triggers significant early inflammatory responses in the lung interstitium and alveoli.
    • These early post-traumatic lung reactions share similarities with the pathogenesis of ARDS.
    • Further research into early management strategies for lung contusion is warranted.