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Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
Published on: June 5, 2019
Histochemical alterations in one lung ventilation
Kingsley Yin1, Elizabeth Gribbin, Steven Emanuel
1Department of Cell Biology, University of Medicine and Dentistry, NJ-School of Osteopathic Medicine, Stratford, New Jersey 08084, USA. yinki@umdnj.edu
The Journal of Surgical Research
|November 23, 2006
Summary
One lung ventilation (OLV) causes lung vascular injury and reduced nitric oxide production, but not inflammation. Histological changes include vascular congestion and alveolar wall thickening after reventilation.
Area of Science:
- Pulmonary Medicine
- Surgical Pathology
- Cardiovascular Physiology
Background:
- One lung ventilation (OLV) is a common surgical procedure.
- OLV can cause pathophysiological alterations like hypoxic vasoconstriction and intrapulmonary shunting.
- Limited data exists on OLV's effects on lung histology.
Purpose of the Study:
- To investigate the histological effects of one lung ventilation on lung tissue.
- To assess changes in nitric oxide production and inflammatory markers during and after OLV.
Main Methods:
- Yorkshire pigs underwent anesthesia and tracheotomy.
- One lung ventilation (OLV) was induced by clamping the right main bronchus for 60 minutes.
- Lung biopsies and blood samples were collected at various time points for histological and biochemical analysis.
Main Results:
- The non-ventilated lung collapsed during OLV.
- Histology revealed vascular congestion and alveolar wall thickening upon reventilation.
- Serum nitrite levels significantly decreased, indicating reduced nitric oxide production.
- No significant increase in lung MPO activity or serum TNF-alpha was observed.
Conclusions:
- One lung ventilation induces lung vascular injury.
- This injury is associated with decreased nitric oxide production.
- The observed lung injury is not linked to an inflammatory response.
