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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites

Georgia B McGaughey1, Dennis Colussi, Samuel L Graham

  • 1Department of Molecular Systems, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA. georgia_mcgaughey@merck.com

Bioorganic & Medicinal Chemistry Letters
|November 23, 2006
PubMed

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