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Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers
Ahmed Kamal1, D Rajasekhar Reddy, P S Murali Mohan Reddy
1Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
Bioorganic & Medicinal Chemistry Letters
|November 23, 2006
Abstract:
C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (DeltaTm) of 18.8 degrees C after incubation of 36 h at 37 degrees C.
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