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Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA
G Tzimagiorgis1, N K Moschonas
1Department of Biology, University of Crete, Greece.
Biochimica Et Biophysica Acta
|June 13, 1991
Abstract:
We isolated and analysed a full-length mouse brain glutamate dehydrogenase (GLUD) cDNA as a preliminary step to use the mouse model for the investigation of GLUD function in neurotransmission and neurodegeneration. GLUD coding sequences were found highly conserved among mouse, human and rat. Northern blots revealed two transcripts with different ratios in different mouse organs implying some mechanism of tissue-specific expression. In contrast to human, mouse GLUD gene family appears not to contain an intronless member.