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Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-IV: Diagnostic and Management

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Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

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Related Experiment Video

Updated: Jul 18, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Elevated neopterin levels in non-allergic asthma.

A Mota Pinto¹, A Todo Bom, S Vale Pereira

¹General Pathology Institute, Faculty of Medicine, Coimbra University, Portugal.

Pathophysiology : the Official Journal of the International Society for Pathophysiology

|November 23, 2006

Summary

Neopterin levels may help classify asthma, particularly in older adults. Non-allergic asthma patients showed higher neopterin than controls, while allergic patients had similar levels to controls.

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Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

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Last Updated: Jul 18, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Immunology
Respiratory Medicine
Geriatrics

Background:

Neopterin, a marker of cell-mediated immune activation, is synthesized by macrophages stimulated by interferon-gamma (IFN-gamma).
Asthma in the elderly is often underdiagnosed, highlighting the need for better diagnostic tools and understanding of its immunoinflammatory pathways.

Purpose of the Study:

To investigate neopterin levels in long-lasting asthma, differentiating between allergic and non-allergic phenotypes in elderly patients.
To assess neopterin's potential as a marker for Th1 immune response in asthma classification.

Main Methods:

Evaluated allergic parameters (skin prick tests, IgE, eosinophils) and serum neopterin levels in 64 asthmatic patients (age >65) and 41 healthy controls.
Compared neopterin and allergic marker levels between allergic and non-allergic asthmatic subgroups and with the control group.

Main Results:

Non-allergic asthmatic patients exhibited significantly higher neopterin levels (4.0+/-4.7 ng/ml) compared to controls (2.1+/-1.9 ng/ml).
Allergic asthmatic patients showed neopterin levels similar to controls (2.4+/-2.8 ng/ml) and lower than non-allergic asthmatics.
Higher neopterin levels (>2.1 ng/ml) correlated with lower IgE levels in asthmatic patients.

Conclusions:

Serum neopterin may serve as a valuable biomarker for distinguishing between allergic and non-allergic asthma phenotypes, especially in elderly populations.
Findings suggest distinct immunoinflammatory profiles in allergic versus non-allergic asthma, potentially aiding in disease classification and management.