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Published on: February 23, 2020
Occupational acrylonitrile exposure and lung cancer: a meta-analysis
Zheng Sponsiello-Wang1, Edward Sanders, Rolf Weitkunat
1Philip Morris Products SA, Research and Development, Product Risk Management, Quai Jeanrenaud 56, Neuchâtel, Switzerland. zheng.wang@pmintl.com
Abstract:
The present work summarizes the currently available published studies on lung cancer and occupational acrylonitrile exposure. Meta-analytic methods were used to estimate the overall risk. To adjust for the healthy worker effect, rate ratio estimates based on regression analyses and ratios of standard mortality ratios were aggregated. Overall effect estimates were 0.95 (95% CI 0.86 to 1.06) and 1.25 (95% CI 1.10 to 1.43) before and after adjustment for the healthy worker effect, respectively. Therefore, a 25% increase in lung cancer risk attributable to occupational acrylonitrile exposure is suggested. Possible contribution of smoking confounding the increased risk cannot be fully excluded.
