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Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
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Increased mortality with FLA compared with ADE chemotherapy in high-risk AML
Blood
|November 23, 2006
Summary
No abstract available in PubMed .
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

