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Related Experiment Videos

Calcium channel auxiliary subunits.

Tsai-Tien Tseng1, Allison M McMahon, Robert J Zahm

  • 1Center for Biophysics and Computational Biology, University of Illinois, Urbana-Champaign, IL, USA. ttseng@vt.edu

Journal of Molecular Microbiology and Biotechnology
|November 23, 2006
PubMed
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Auxiliary subunits modify transporter activity and biogenesis. This review examines voltage-gated calcium channel auxiliary subunits in animals, exploring their functions, evolution, and novel homologues.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Transporters, including ion channels, often associate with auxiliary subunits.
  • These subunits modulate transporter function and aid in their cellular assembly (biogenesis).
  • Recent research focuses on calcium channel auxiliary subunits due to their pharmacological relevance.

Purpose of the Study:

  • To review the functions of auxiliary subunits of voltage-gated calcium channels in animals.
  • To analyze the evolutionary origins and phylogenetic relationships of these subunits.
  • To identify novel auxiliary subunit homologues.

Main Methods:

  • Literature review of functional data for calcium channel auxiliary subunits.
  • Phylogenetic analysis of subunit sequences.

Related Experiment Videos

  • Comparative genomics to identify novel homologues.

    • Main Results:

    • Detailed evaluation of known auxiliary subunit functions in calcium ion conductance.
    • Phylogenetic analyses revealing evolutionary connections.
    • Identification of previously undiscovered homologous subunits.

    Conclusions:

    • Auxiliary subunits are crucial for transporter regulation and biogenesis.
    • Voltage-gated calcium channel auxiliary subunits in animals serve as a model for transporters generally.
    • The identified novel homologues warrant further investigation by the scientific community.