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Clinical manifestations of hemoglobin Chico at high altitude

Cindi R Starkey1, Lea Davies, James D Hoyer

  • 1Department of Pathology, The University of New Mexico, Albuquerque, NM, USA.

Journal of Pediatric Hematology/Oncology
|November 23, 2006
PubMed

Hemoglobin Chico is a rare hemoglobinopathy characterized by low oxygen affinity and a right-shifted oxygen dissociation curve. Detailed clinical evaluations of affected individuals have not been previously reported. We therefore report on the clinical features of Hemoglobin Chico in a Latino male living at high altitude, who desired to participate in school sports. As a young boy with asthma, he had the unusual finding of growth delay and digital clubbing which improved with asthma control. At 16 years of age, he had mild anemia and a decreased pulse oximetry (83%) but sufficient pulmonary reserve to participate in physically demanding activities.

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