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Updated: Jul 18, 2026
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Introduction to Solid Supported Membrane Based Electrophysiology
Published on: May 11, 2013
Transporter assays using solid supported membranes: a novel screening platform for drug discovery
Bela Kelety1, Kerstin Diekert, Joanna Tobien
1IonGate Biosciences, Frankfurt, Germany.
Assay and Drug Development Technologies
|November 23, 2006
Summary
A new drug discovery platform using solid supported membranes enables high-throughput transporter assays. This technology addresses a critical need for studying membrane proteins like peptide transporters and proton pumps in drug development.
Area of Science:
- Biochemistry
- Pharmacology
- Membrane Protein Research
Background:
- Transporter proteins are crucial targets in drug discovery.
- Existing high-throughput assays for membrane transporters are limited.
- Solid supported membrane technology offers a potential solution.
Purpose of the Study:
- To introduce a novel drug discovery platform based on solid supported membranes.
- To demonstrate the platform's capability for high-throughput transporter assays.
- To highlight the potential impact on identifying new drug candidates.
Main Methods:
- Development of a drug discovery platform utilizing solid supported membranes.
- Implementation of functional assays for specific transporter proteins.
- Testing the platform with assays for H(+)-dependent peptide transporter 1 (PepT1), gastric proton pump, and Na(+)/Ca(2+) exchanger.
Main Results:
- Successful establishment of a novel platform for membrane transporter research.
- Demonstration of functional transporter assays on solid supported membranes.
- Validation of the platform's applicability to diverse transporter targets.
Conclusions:
- The novel solid supported membrane platform provides a high-throughput solution for transporter assay development.
- This technology is poised to significantly advance drug discovery efforts targeting membrane proteins.
- The platform facilitates the study of key transporters, including PepT1, proton pumps, and ion exchangers.
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