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Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Kenji Dohi1, Kazue Satoh, Tomoya Nakamachi
1Showa University, Department of Emergency and Critical Care Medicine, Tokyo, Japan. kdop@med.showa-u.ac.jp
Abstract:
Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
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