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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Published on: June 2, 2014

A clinical study of migraine evolution.

William Pryse-Phillips1, Michel Aubé, Peter Bailey

  • 1Memorial University, St. John's, Newfoundland, Canada.

Headache
|November 23, 2006
PubMed
Summary

Migraine attacks can last over 72 hours and have delayed pain buildup in 10% of patients. Nausea frequently interferes with oral medication, but treatments remain effective for most migraine sufferers.

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Area of Science:

  • Neurology
  • Clinical Neuroscience
  • Headache Medicine

Background:

  • Migraine headache duration and buildup time are not well-defined in existing literature.
  • Some patients experience migraines exceeding 72 hours, necessitating further investigation.
  • Understanding these factors can optimize therapeutic strategies for migraine management.

Purpose of the Study:

  • To delineate the buildup time and duration of migraine headaches in a clinical setting.
  • To assess the impact of nausea on oral medication efficacy.
  • To compare migraine characteristics in patients with and without aura.

Main Methods:

  • Prospective data collection from 253 patients with International Headache Society (IHS) defined migraine.
  • Utilized questionnaires completed by patients consulting Canadian headache specialists.
  • Data were electronically transmitted, tabulated, and statistically analyzed.

Main Results:

  • Nausea occurred in over 90% of migraine cases, particularly those with aura, hindering oral medication intake in approximately 25% of patients.
  • Migraine pain buildup to severe levels was under 2 hours in most patients (97% with aura, 86% without aura), but delayed in over 10% of cases.
  • While most migraines lasted 4-72 hours, over 20% of patients experienced pain exceeding 72 hours, with disability persisting for over 3 days in a significant portion.

Conclusions:

  • Real-world migraine attacks often deviate from IHS criteria, featuring more frequent nausea impacting oral therapy, longer durations (>72 hours), and delayed pain progression (>2 hours in 10%).
  • Despite these variations, current therapeutic regimens are effective for a substantial majority of migraine patients.
  • The study highlights the need to consider prolonged migraine duration and delayed onset in clinical assessments and treatment planning.