Related Experiment Video

Updated: Jul 18, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Circadian and seasonal variation of migraine attacks in children

Stefano Soriani1, Elisa Fiumana, Roberto Manfredini

  • 1Department of Clinical and Experimental Medicine--Pediatrics, University of Ferrara, 44100 Ferrara, Italy.

Headache
|November 23, 2006
PubMed

Insights

Pediatric migraine without aura shows distinct daily and seasonal patterns, with attacks peaking in the morning and afternoon, and during autumn-winter months. These patterns suggest school activities may influence migraine occurrence in children.

Area of Science:

  • Neurology
  • Pediatrics
  • Chronobiology

Background:

  • Migraine is a common neurological disorder in children.
  • Understanding the temporal patterns of pediatric migraine is crucial for effective management.
  • Migraine without aura is the most frequent type in pediatric populations.

Purpose of the Study:

  • To investigate the circadian and seasonal rhythmicity of migraine episodes without aura in children.
  • To identify specific time intervals with increased migraine attack frequency.
  • To explore potential triggers related to temporal patterns.

Main Methods:

  • A prospective study involving 115 children diagnosed with migraine without aura.
  • Recording of 2517 migraine attack occurrences using daily diaries.
  • Analysis of attack times at hourly and monthly intervals to identify temporal variations.

Main Results:

  • A significant circadian variation in migraine attacks was observed, with peaks in the early morning and afternoon.
  • A distinct seasonal pattern emerged, with a peak incidence between November and January.
  • The lowest frequency of migraine attacks occurred in July.

Conclusions:

  • Pediatric migraine without aura exhibits significant circadian and seasonal variations.
  • The clustering of attacks in the morning/midday and during autumn-winter suggests a link to daily routines.
  • School activities are hypothesized as a potential contributing factor to migraine frequency in children.
Abstract

More Related Videos

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies05:49

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

Published on: November 1, 2024

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Nightmares and Night Terrors01:18

Nightmares and Night Terrors

Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares often...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...