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Related Experiment Videos

Reduced lung function predicts increased fatality in future cardiac events. A population-based study.

G Engström1, B Hedblad, L Janzon

  • 1Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden. gunnar.engstrom@med.lu.se

Journal of Internal Medicine
|November 23, 2006
PubMed
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Reduced lung function, indicated by lower forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1), is linked to increased fatality from coronary events in apparently healthy men.

Area of Science:

  • Cardiology
  • Pulmonology
  • Epidemiology

Background:

  • Reduced lung function is associated with coronary event incidence.
  • The link between lung function and coronary event fatality remains unclear.

Purpose of the Study:

  • To investigate if reduced forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) in healthy men predict the fatality of future coronary events.

Main Methods:

  • Prospective, population-based cohort study in Malmö, Sweden.
  • Followed 5452 healthy men (28-61 years) for a mean of 19 years.
  • Assessed the relationship between FVC, FEV1, and coronary event incidence and fatality.

Main Results:

  • Low FVC or FEV1 correlated with increased incidence of fatal and non-fatal coronary events.

Related Experiment Videos

  • Men with reduced lung function experienced higher case-fatality rates after a coronary event.
  • Adjusted odds ratios for one-day mortality increased with lower FVC quartiles (trend: P < 0.05).

    • Conclusions:

    • Moderately reduced lung function in healthy men is associated with higher fatality from subsequent coronary events.
    • This includes a greater proportion of coronary heart disease deaths and fewer non-fatal myocardial infarctions.