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Colitis in a renal transplant patient with human herpesvirus-6 infection
M S Delbridge1, M S Karim, B M Shrestha
1Sheffield Kidney Institute, Sheffield, UK. Michael.Delbridge@sth.nhs.uk
Abstract:
A male patient developed colitis and a thrombotic microangiopathy 3 weeks after renal transplantation. Immunosuppression at the time of presentation was with sirolimus, mycophenolate mofetil, and prednisolone, but without a calcineurin inhibitor. Cytomegalovirus infection was excluded. However, human herpesvirus-6 DNA was detected at high copy number in both blood and colonic epithelium. The patient recovered after reduction in immunosuppression, with nutritional support and ganciclovir therapy.
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