Related Experiment Video
Updated: Jul 18, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Recurrent genomic imbalances in primary effusion lymphomas
Prakash Nair1, Hongyi Pan, Raymond L Stallings
1Children's Cancer Research Institute and Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Primary effusion lymphoma (PEL), an AIDS-related cancer, often involves Kaposi's sarcoma-associated herpesvirus (KSHV). This study identifies specific chromosomal gains in KSHV-positive PEL cell lines, suggesting their role in disease development.
Area of Science:
- Oncology
- Virology
- Genetics
Background:
- Primary effusion lymphoma (PEL) is an aggressive AIDS-related lymphoma with a poor prognosis.
- Kaposi's sarcoma-associated herpesvirus (KSHV) is frequently detected in PEL, but its role in pathogenesis remains unclear.
Purpose of the Study:
- To investigate chromosomal imbalances in KSHV-positive PEL cell lines.
- To identify specific genomic regions associated with PEL development.
Main Methods:
- Comparative genomic hybridization (CGH) analysis was performed on six KSHV-positive PEL cell lines.
- Identification of recurrent chromosomal gains and their overlapping regions.
Main Results:
- Genomic gains were observed on chromosomes 1q31, 4q31-q33, 7q10-q21, 8q21.1, 12q0-q23, and Xp11-q21.
- These gains were recurrent across the analyzed PEL cell lines.
Conclusions:
- Recurrent chromosomal gains in KSHV-positive PEL cell lines indicate their potential involvement in the pathogenesis of PEL.
- Further research into these genomic alterations may reveal therapeutic targets for PEL.
More Related Videos
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
09:02Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Related Concept Videos
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Non-LTR Retrotransposons