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Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells
1Unit of Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.
Neuroscience Letters
|January 14, 1991
Abstract:
The effect of acute ethanol (EtOH) exposure on 5-HT3 receptor-mediated ion current was examined in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. EtOH potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner at concentrations (25-100 mM) which are achieved during EtOH intoxication in vivo.