Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Allergic Reactions

Allergic Reactions

Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

General Anesthesia: Overview

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Valve Deterioration After Supra-Annular Transcatheter Aortic Valve Replacement: Impact of Annular Size and Gradient.

JACC. Asia·2026

Same author

Reimbursement policy and outcomes after transcatheter aortic valve implantation.

Journal of the Chinese Medical Association : JCMA·2026

Same author

Prospective response surface modeling of analgesia nociception index using propofol, fentanyl and sevoflurane synergism for laryngeal mask airway placement.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026

Same author

Target-controlled infusion achieves smoother autonomic modulation than manual bolus during propofol induction: Evidence from wavelet-based spectral analysis.

Journal of the Chinese Medical Association : JCMA·2026

Same author

Enhancing Anesthetic Depth Assessment via Unsupervised Machine Learning in Processed Electroencephalography Analysis: Novel Methodological Study.

JMIR medical informatics·2026

Same author

Blood Pressure Discrepancy Between Arm and Finger as a Predictor of Intradialytic Hypotension: A Pilot Study.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2025

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Clindamycin-induced anaphylactic shock during general anesthesia.

Chiuan-Shiou Chiou¹, Su-Man Lin, Shih-Pin Lin

¹Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan.

Journal of the Chinese Medical Association : JCMA

|November 23, 2006

Summary

Clindamycin can cause rare but severe anaphylactic shock, even during surgery. Promptly stopping the drug and providing resuscitation is crucial for patient survival.

Related Experiment Videos

Last Updated: Jul 18, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Area of Science:

Anesthesiology
Pharmacology
Oncology

Background:

Anaphylactic reactions to clindamycin are uncommon.
Perioperative anaphylactic shock presents diagnostic challenges and carries significant risks.

Observation:

A male patient with buccal cancer experienced life-threatening anaphylactic shock post-intravenous clindamycin during radical neck dissection.
The patient received immediate cardiopulmonary resuscitation and recovered without complications.

Findings:

Intravenous clindamycin administration can precipitate severe anaphylactic shock in surgical patients.
Early recognition and cessation of the offending agent are critical for managing anaphylaxis.

Implications:

This case highlights the importance of vigilance for rare adverse drug reactions during surgical procedures.
Immediate intervention protocols for perioperative anaphylaxis are essential for patient safety.