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Osteoporosis in men.

Neil Binkley1

  • 1Osteoporosis Clinical Center and Research Program, Institute on Aging, University of Wisconsin, Madison, WI 53705, USA. nbinkley@wisc.edu

Arquivos Brasileiros De Endocrinologia E Metabologia
|November 23, 2006
PubMed
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Osteoporosis affects many men, yet is often overlooked. While hormone therapy shows promise, bisphosphonates are the current standard for treating male osteoporosis and reducing fracture risk.

Area of Science:

  • Endocrinology
  • Geriatrics
  • Orthopedics

Background:

  • Osteoporosis, a skeletal disease causing fragility fractures, affects 40-50% of women and 25-33% of men.
  • Historically, research focused on female osteoporosis, leading to neglect in understanding and treating the condition in men.
  • Both testosterone and estrogen play roles in skeletal health, with emerging evidence suggesting estrogen's dominant role in both sexes.

Purpose of the Study:

  • To highlight the significance of osteoporosis in men.
  • To review diagnostic criteria and therapeutic options for male osteoporosis.
  • To assess the efficacy of current and potential treatments for reducing fracture risk in men.

Main Methods:

  • Review of existing literature on male osteoporosis.

Related Experiment Videos

  • Analysis of diagnostic criteria, including bone mineral density (BMD) T-scores.
  • Evaluation of therapeutic interventions such as androgen therapy, parathyroid hormone, and bisphosphonates.

    • Main Results:

    • Bone mineral density (BMD) measurement and a T-score of -2.5 or below are recommended for diagnosing osteoporosis in men.
    • Androgen therapy may be considered for hypogonadal men, but lacks data on fracture risk reduction.
    • Parathyroid hormone increases BMD, but studies are insufficient to confirm fracture reduction efficacy.
    • Bisphosphonate therapy is effective in increasing BMD and reducing vertebral fracture risk, establishing it as the standard of care for osteoporotic men.

    Conclusions:

    • Osteoporosis in men requires greater recognition and research.
    • Bisphosphonates are the current standard of care for treating male osteoporosis due to proven efficacy in reducing vertebral fractures.
    • Further research is needed to establish the long-term fracture reduction efficacy of other treatments like androgen therapy and parathyroid hormone.