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Published on: April 7, 2023
Drug evaluation: apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis
Mohamed M Thabet1, Tom W J Huizinga
1Leiden University Medical Center, Department of Rheumatology, Albinusdreef 2, 2300 RC Leiden, The Netherlands. M.Thabet@lumc.nl
Abstract:
Wyeth Research was developing apratastat (TMI-005), one in a series of dual TNFalpha-converting enzyme and matrix metalloprotease-13 inhibitors, for the potential treatment of inflammation, especially rheumatoid arthritis. By January 2005, apratastat had entered a phase II clinical trial; however, in October 2006, Wyeth reported that it had terminated development of the drug because of lack of efficacy in this trial.