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Docetaxel labeled with iodine 131 radionuclide--a possible new anticancer drug? (The pilot study)
Jirí Pastera1, Emil Rudolf, Milan Dittrich
1Institute of Experimental Biopharmaceutics, Joint Research Center of Czech Academy of Sciences and PRO.MED.CS, Hradec Králové, Czech Republic. pastera@uebf.cas.cz
Abstract:
The cytotoxic potentials of the lipiodol emulsion with dissolved 131I-docetaxel, the 131I-lipiodol emulsion and non-labeled docetaxel were tested on the HeLa Hep2 cell line during 24 hours. The pilot study confirmed that the radio-labeled docetaxel was significantly more toxic than the radionuclide or docetaxel alone.
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