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Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits
1Department of Neurophysiology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Acta Neurochirurgica
|January 1, 1991
Abstract:
The present study deals with the effects of immunomodulators on the morphology of intracerebral arterial walls in rabbits with experimental subarachnoid haemorrhage (SAH). Immunostimulators:thymostimuline and inosine dimethylamino-isopropanol-p-acetamido-benzoate were found to aggravate the angiopathic changes, whereas immunosuppressive drugs-cyclosporine A and azathioprine appeared to prevent the damage. The authors consider the possibility of using immunosuppressive drugs in patients with ruptured intracranial aneurysms.