Isolated amyloidosis presenting with lumbosacral radiculoplexopathy: description of two cases and pathogenic review
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Updated: Jul 18, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Shafeeq S Ladha1, P James B Dyck, Robert J Spinner
1Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Abstract:
In this study, we present two cases of infiltrative, localized amyloidosis involving lumbosacral root and plexus, e.g., isolated amyloidomas. Rare and poorly understood amyloidomas may occur in both neurologic and non-neurologic tissues. The described cases emphasize potential for localized peripheral amyloidomas: (1) potential for associated lambda light chain lymphoplasmacytic lymphoma association; (2) e isolated amyloidosis without evidence for systemic plasma cell dyscrasia; (3) features suggestive of potential pathogenesis; and (4) discussion of treatment options including immunotherapy and resection. The limited literature and experience among other cases is described.
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