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[Fibrinolytic activity in traumatic hemothorax fluids]
J F Schved1, J C Gris, D Gilly
1Laboratoire d'Hématologie et Immunologie, CHRU de Nîmes.
Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1991
Summary
Trauma-induced hemothorax shows high D-dimer levels, indicating significant fibrinolysis. This suggests rapid coagulation activation followed by fibrinolytic reactions in pleural fluid after injury.
Area of Science:
- Biochemistry
- Hematology
- Trauma Medicine
Context:
- Hemothorax, a common complication of trauma, involves blood accumulation in the pleural space.
- Understanding the hemostatic and fibrinolytic processes in hemothorax is crucial for patient management.
Purpose:
- To investigate the hemostatic and fibrinolytic parameters in the pleural fluid of trauma patients with hemothorax.
- To explore potential mechanisms underlying fibrinogen levels in hemothorax.
Summary:
- Studied 29 trauma patients with hemothorax, analyzing pleural fluid for clotting fibrinogen, D-dimers, plasminogen, alpha 2-antiplasmin, alpha 2-macroglobulin, tissue plasminogen activator (tPA Ag), plasminogen activator inhibitor (PAI), and hematocrit.
- Results showed very high D-dimer levels and low clotting fibrinogen, with other fibrinolytic factors present.
- A significant inverse correlation was found between D-dimer and alpha 2-macroglobulin.
Impact:
- Findings suggest rapid coagulation activation followed by intense fibrinolysis in hemothorax.
- The study highlights the role of plasminogen and tPA in the pleural fluid's fibrinolytic activity.
- These insights may inform future diagnostic and therapeutic strategies for hemothorax.