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Updated: Jul 18, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Fibroblast growth factors as regulators of stem cell self-renewal and aging
Joyce S G Yeoh1, Gerald de Haan
1Department of Cell Biology, Section Stem Cell Biology, University Medical Centre Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Abstract:
Organ and tissue dysfunction which is readily observable during aging results from a loss of cellular homeostasis and reduced stem cell self-renewal. Over the past 10 years, studies have been aimed at delineating growth factors that will sustain and promote the self-renewal potential of stem cells and support the expansion of primitive stem cells in vitro and in vivo. Recently, strong evidence is emerging indicating that fibroblast growth factors (FGFs) play a crucial role in stem cell maintenance. FGFs belong to a family of polypeptide growth factors that are involved in multiple functions including cell proliferation, differentiation, survival and motility. In this review, we discuss the regulatory role of FGFs on hematopoietic stem cells (HSCs), neural stem cells (NSCs) and embryonic stem (ES) cells in maintaining stem cell self-renewal. These findings are useful and important to further our knowledge in stem cell biology and for therapeutic approaches.
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