Related Experiment Video
Updated: Jul 18, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
A systematic review on drug interactions in oncology
Rachel P Riechelmann1, Everardo D Saad
1Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Canada. Rachel.Riechelmann@uhn.on.ca
Objectives:
To systematically review drug interactions in oncology.
Methods:
We searched PubMed for eligible articles and online databases abstracts of major oncology meetings from 2002 to 2005.
Results:
One study reported on the frequency of drug interactions. Interactions between chemotherapy and nonchemotherapy agents have been reported mostly in small clinical trials and case series. Interactions between chemotherapic agents have been reported mostly in Phase I studies. Few studies described fatal outcomes of drug interactions in cancer patients.
Conclusion:
Drug interactions comprise an important issue in oncology, but very limited data exist on their frequency and clinical consequences.
More Related Videos
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
09:19Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Related Concept Videos
Drug toxicity: Drug–Drug Interaction
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Pharmacokinetics: Drug–Drug Interactions
Treatment Resistant Cancers
Pharmacokinetics: Drug–Food and Drug–Viral Interactions