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Updated: Jul 18, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
The T-cell antigen receptor: a logical response to an unknown ligand
1Laboratory of Transplantation Immunology, Departments of Nephrology and Research, University Hospital Basel, Basel, Switzerland. Ed.Palmer@unibas.ch
Abstract:
The immune system can be roughly divided into innate and adaptive compartments. The adaptive compartment includes the B and T lymphocytes, whose antigen receptors are generated by recombination of gene segments. The consequence is that the creation of self-reactive lymphocytes is unavoidable. For the host to remain viable, the immune system has evolved a strategy for removing autoimmune lymphocytes during development. This review discusses how T lymphocytes are generated, how they recognize antigens, and how their antigen receptor directs the removal of self-reactive T cells.
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