GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia
1Institute of Pharmacology, University of Zurich, Zurich, Switzerland. mohler@pharma.unizh.ch
Abstract:
Brain function is based on an exquisite balance between excitatory and inhibitory neurotransmission. GABAergic neurons provide the major inhibitory control. By controlling spike timing and sculpting neuronal rhythms they play a key role in regulating behavior. GABAergic neurons are highly diverse and operate with a corresponding diversity of GABAA receptor subtypes. In this article, the contribution of GABAA receptor deficits to central nervous system disorders, in particular anxiety disorders, epilepsy, schizophrenia and insomnia, is reviewed.
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