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Related Experiment Video

Updated: Jul 18, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Malignant melanoma and pregnancy.

Vitaliano Silipo¹, Paola De Simone, Giustino Mariani

¹Department of Dermatology-Oncology, S Gallicano Dermatological Institute, Via Elio Chianesi, Rome, Italy.

Melanoma Research

|November 23, 2006

Summary

Pregnancy does not significantly impact malignant melanoma outcomes. This study found no difference in survival rates between pregnant and non-pregnant women diagnosed with melanoma, emphasizing close skin lesion monitoring during pregnancy.

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

Oncology
Dermatology
Obstetrics

Background:

Malignant melanoma during pregnancy is rare, with conflicting reports on its prognosis.
Some studies suggest hormonal influences (progesterone, estrogen) worsen melanoma prognosis in pregnant women.
Other research indicates diagnosis timing during pregnancy does not affect mortality risk.

Purpose of the Study:

To evaluate the clinical and biological behavior of malignant melanomas diagnosed during pregnancy.
To compare outcomes and survival rates of melanoma in pregnant versus non-pregnant women.
To assess the influence of pregnancy on melanoma prognosis.

Main Methods:

Retrospective review of malignant melanoma cases diagnosed during pregnancy (1991-2000).
Analysis of patient age, histological type, tumor thickness, disease stage, and surgical management.
Comparison with melanoma cases in non-pregnant women over the same period with a 5-year follow-up.

Main Results:

No significant difference in outcome or survival rates was observed between pregnant and non-pregnant women with melanoma.
Melanocytic skin lesions exhibit transient dermoscopic pattern modifications during pregnancy.
Close clinical and instrumental follow-up of pigmented lesions is crucial during pregnancy.

Conclusions:

Pregnancy does not appear to negatively influence the prognosis of malignant melanoma.
Monitoring skin lesions during pregnancy is essential due to potential transient changes.
Identifying other melanoma risk factors remains important for pregnant women.