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Updated: Jul 18, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics
Nicholas M Llewellyn1, Jonathan B Spencer
1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW. nml30@cam.ac.uk
Abstract:
The 2-deoxystreptamine-containing aminoglycosides are an important class of clinically valuable antibiotics. A deep understanding of the biosynthesis of these natural products is required to enable efforts to rationally manipulate and engineer the biological production of novel aminoglycosides. This review discusses the development of our biosynthetic knowledge over the past half-century, with emphasis on the relatively recent contributions of molecular biology to the elucidation of these biosynthetic pathways.
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