Primary liver AIDS-related lympoma.

Area of Science:

• Oncology
• Hepatology
• Infectious Diseases

Background:

• Non-Hodgkin's lymphoma (NHL) is a frequent malignancy in individuals with Acquired Immunodeficiency Syndrome (AIDS).
• Extranodal sites, particularly the digestive tract and central nervous system, are common sites for NHL in AIDS patients.
• Primary liver lymphoma (PLL) is an infrequent presentation of lymphoma in the liver among this population.

Observation:

• This case highlights Primary Liver Lymphoma (PLL) as the initial manifestation of AIDS.
• The patient had no prior history of Hepatitis C or B virus infection.
• The presentation involved multiple and large hepatic masses.

Findings:

• Diagnostic imaging like ultrasonography and computed tomography can suggest focal hepatic lymphoma.
• Image-guided fine-needle biopsy with histopathology is the definitive diagnostic method for hepatic lymphoma.
• This case underscores the importance of considering PLL in the differential diagnosis of liver masses in AIDS patients, even without viral hepatitis markers.

Implications:

• Early and accurate diagnosis of PLL in AIDS patients is critical for timely treatment and improved outcomes.
• This case expands the understanding of NHL presentations in the context of AIDS.
• Further research into the specific risk factors and diagnostic challenges of PLL in immunocompromised individuals is warranted.