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Updated: Jul 18, 2026

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake
Published on: September 21, 2017
Parkinson's disease and dopamine transporter neuroimaging: a critical review
Ming Chi Shih1, Marcelo Queiroz Hoexter, Luiz Augusto Franco de Andrade
1Laboratório Interdisciplinar de Neuroimagem e Cognição, Universidade Federal de São Paulo, Rua Dr. Bacelar 334, CEP 04026-001 São Paulo, Brazil. mingchi@psuquiatria.epm.br
Abstract:
Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson's disease diagnosis (sensitivity and specificity).
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