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[Botulinum toxin treatment for horizontal strabismus in children with cerebral palsy]

Mônica Fialho Cronemberger1, Tomás Scalamandré Mendonça, Harley Edison do Amaral Bicas

  • 1Universidade Federal de São Paulo, São Paulo, SP, Brasil. mfcronemberger@uol.com.br

Arquivos Brasileiros De Oftalmologia
|November 23, 2006
PubMed

Insights

Botulinum toxin injections effectively treated esotropia in children with cerebral palsy, with 47.1% achieving success after one dose. However, it was less effective for exotropia, and common side effects included ptosis and hemorrhage.

Area of Science:

  • Ophthalmology
  • Neurology

Context:

  • Cerebral palsy (CP) often presents with horizontal strabismus.
  • Strabismus significantly impacts visual development and quality of life in affected children.

Purpose:

  • To assess the efficacy of botulinum toxin (BoNT-A) injections for horizontal strabismus in pediatric CP patients.
  • To determine success rates and identify potential side effects of this treatment modality.

Summary:

  • A study treated 24 children (6-156 months) with CP and horizontal strabismus using botulinum toxin. Esotropia patients (n=17) showed a 47.1% success rate with one injection for deviations ≤35 PD after 2 years. Exotropia patients (n=7) did not achieve success with a single injection.
  • Success was defined as ≤10 PD deviation after 6 months, with a second application allowed. Common side effects included transient ptosis (91.7%), subconjunctival hemorrhage (16.7%), and transient vertical deviation (16.7%).

Impact:

  • Botulinum toxin offers a viable treatment alternative for esotropia in children with cerebral palsy.
  • Further research may explore optimizing BoNT-A protocols for exotropia and managing associated side effects in this population.
Abstract

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